RIPASUDIL HYDROCHLORIDE HYDRATE
K-115
CAS: 887375-67-9
Molecular Formula: C15H23ClFN3O4S
RIPASUDIL HYDROCHLORIDE HYDRATE - Names and Identifiers
RIPASUDIL HYDROCHLORIDE HYDRATE - Physico-chemical Properties
| Molecular Formula | C15H23ClFN3O4S |
| Molar Mass | 395.8772232 |
| Solubility | 10 mM in DMSO |
| Storage Condition | -20℃ |
| In vitro study | In monkey trabecular meshwork (TM) cells, Ripasudil induces contraction and encircling of the cell body, as well as disruption of actin bundles. In Schlem's duct endothelial (SCE) cells, Ripasudil significantly reduces transendothelial resistance (TEER), increases or decreases the transmembrane flux of FITC-dextran, and interferes with the cellular localization of ZO-1 expression. |
| In vivo study | Topical instillation of Ripasudil significantly reduced intraocular pressure (IOP) in white rabbits and monkeys, with maximal IOP decreasing by 8.55 mmHg and 4.36 mmHg at 0.5 and 0.4 concentrations, respectively. In a mouse model, Ripasudil (1 mg/kg daily, p.o.) neuroprotective effects on retinal ganglion cells (RGC) following optic nerve injury (NC) by inhibiting oxidative stress in a pathway involving the Nox family. |
RIPASUDIL HYDROCHLORIDE HYDRATE - Risk and Safety
| Risk Codes | R24/25 - R26 - Very Toxic by inhalation R28 - Very Toxic if swallowed |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S41 - In case of fire and / or explosion do not breathe fumes. S48 - To be kept wet with (there follows a material name). |
| HS Code | 29339900 |
RIPASUDIL HYDROCHLORIDE HYDRATE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.526 ml | 12.63 ml | 25.26 ml |
| 5 mM | 0.505 ml | 2.526 ml | 5.052 ml |
| 10 mM | 0.253 ml | 1.263 ml | 2.526 ml |
| 5 mM | 0.051 ml | 0.253 ml | 0.505 ml |
Last Update：2024-01-02 23:10:35
RIPASUDIL HYDROCHLORIDE HYDRATE - Reference Information
| biological activity | Ripasudil (K-115) hydrochloride dihydrate is a potent ROCK Inhibitor, the IC50 for ROCK1 and ROCK2 were 51 nM and 19 nM, respectively, and were used for the treatment of glaucoma and intraocular hypertension. |
| Target | Value |
| ROCK2 (Cell-free assay) | 19 nM |
| ROCK1 (Cell-free assay) | 51 nM |
Last Update：2024-04-09 21:11:58
Supplier List
Product Name: K-115 Visit Supplier Webpage Request for quotation
CAS: 887375-67-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 887375-67-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: K-115 Visit Supplier Webpage Request for quotation
CAS: 887375-67-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 887375-67-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History